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Systemic Medication: Diltiazem in familial primary hyperhidrosis
Several members of a family suffering from an apparent autosomal
dominant form of primary focal hyperhidrosis had a marked
reduction in sweat output with the use of the calcium channel
blocker diltiazem.[66]
Studies have suggested that sweat output is in part initiated
by an influx of calcium from the extracellular space into
the secretory cells of the eccrine gland.[118]
Calcium channel blockers prevent the influx of calcium across
cell membranes and thus may be useful in hyperhidrosis. A
search of the medical literature using Medline, however, found
no further published reports of calcium channel blockers in
the treatment of hyperhidrosis.
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